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Original Articles
- Accelerated and Exacerbated Effects of High Dietary Fat on Neuronal Damage Induced by Transient Cerebral Ischemia in the Gerbil Septum
- Seung Hwan Cheon, Bing Chun Yan, Bai Hui Chen, Joon Ha Park, Ji Hyeon Ahn, In Hye Kim, Jae-Chul Lee, Yoo Seok Park, Min Joung Kim, Yun Lyul Lee, Jun Hwi Cho, Moo-Ho Won
- Endocrinol Metab. 2014;29(3):328-335. Published online September 25, 2014
- DOI: https://doi.org/10.3803/EnM.2014.29.3.328
- 3,538 View
- 29 Download
- 8 Web of Science
- 8 Crossref
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Abstract
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PubReader Background Obesity induced by high-fat diet (HFD) is one of the most widespread metabolic disorders in current society. However, there has been little research regarding the effects of HFD-induced obesity in the septa of animal models of cerebral ischemia. Therefore, in the present study, we investigated septal effects of HFD on neuronal damage and gliosis induced by transient cerebral ischemia.
Methods Body weight, blood glucose levels and serum lipid profiles levels were measured both in the normal diet (ND) and HFD-group. We also investigated the effects of ND and HFD on neuronal damage and gliosis in the septum after transient cerebral ischemia using immunohistochemistry.
Results The levels of blood glucose, serum triglyceride, and total cholesterol were significantly increased in the HFD-fed gerbils compared with the ND-fed gerbils, although body weight was not significantly changed after HFD feeding. In the ND-fed gerbils, ischemia-induced neuronal damage was found in the septohippocampal nucleus (SHN) of the septum 7 days after ischemia. In the HFD-fed gerbils, ischemia-induced neuronal damage in the SHN was much more severe compared with that of the ND-fed gerbils 4 and 7 days after ischemia. In addition, we found that ischemia-induced glial activation including astrocytes and microglia was accelerated and exacerbated in the HFD-fed gerbils compared with that in the ND-fed gerbils.
Conclusion These results indicate that HFD can lead to much more severe effects in ischemia-induced neuronal damage/death in the septum after ischemia-reperfusion, and that it may be associated with accelerated change in glial activation.
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Citations
Citations to this article as recorded by
- Ischemic stroke, obesity, and the anti‐inflammatory role of melatonin
Nuttapong Yawoot, Piyarat Govitrapong, Chainarong Tocharus, Jiraporn Tocharus
BioFactors.2021; 47(1): 41. CrossRef - Analysis of knowledge bases and research focuses of cerebral ischemia-reperfusion from the perspective of mapping knowledge domain
Yi Qin, Qing Zhang, Yaru Liu
Brain Research Bulletin.2020; 156: 15. CrossRef - High fat diet accelerates and exacerbates microgliosis and neuronal damage/death in the somatosensory cortex after transient forebrain ischemia in gerbils
Won Joo Seo, Ji Hyeon Ahn, Tae-Kyeong Lee, Bora Kim, Jae-Chul Lee, Joon Ha Park, Yeon Ho Yoo, Myoung Cheol Shin, Jun Hwi Cho, Moo-Ho Won, Yoonsoo Park
Laboratory Animal Research.2020;[Epub] CrossRef - A 2-Min Transient Ischemia Confers Cerebral Ischemic Tolerance in Non-Obese Gerbils, but Results in Neuronal Death in Obese Gerbils by Increasing Abnormal mTOR Activation-Mediated Oxidative Stress and Neuroinflammation
Joon Ha Park, Ji Hyeon Ahn, Minah Song, Hyunjung Kim, Cheol Woo Park, Young Eun Park, Tae-Kyeong Lee, Jae-Chul Lee, Dae Won Kim, Choong-Hyun Lee, In Koo Hwang, Bing Chun Yan, Sungwoo Ryoo, Young-Myeong Kim, Il Jun Kang, Moo-Ho Won, Soo Young Choi
Cells.2019; 8(10): 1126. CrossRef - Prolonged High Fat Diet Worsens the Cellular Response to a Small, Covert-like Ischemic Stroke
Kathleen E. Fifield, Todd M. Rowe, Joanna B. Raman-Nair, Michiru Hirasawa, Jacqueline L. Vanderluit
Neuroscience.2019; 406: 637. CrossRef - Antioxidant Properties of Fucoidan Alleviate Acceleration and Exacerbation of Hippocampal Neuronal Death Following Transient Global Cerebral Ischemia in High-Fat Diet-Induced Obese Gerbils
Ji Ahn, Myoung Shin, Dae Kim, Hyunjung Kim, Minah Song, Tae-Kyeong Lee, Jae-Chul Lee, Hyeyoung Kim, Jun Cho, Young-Myeong Kim, Jong-Dai Kim, Soo Choi, Moo-Ho Won, Joon Park
International Journal of Molecular Sciences.2019; 20(3): 554. CrossRef - Obesity and stroke: Can we translate from rodents to patients?
Michael J Haley, Catherine B Lawrence
Journal of Cerebral Blood Flow & Metabolism.2016; 36(12): 2007. CrossRef - Articles in 'Endocrinology and Metabolism' in 2014
Won-Young Lee
Endocrinology and Metabolism.2015; 30(1): 47. CrossRef
- Ischemic stroke, obesity, and the anti‐inflammatory role of melatonin
- Lipid Profiles and Prevalence of Dyslipidemia in Korean Adolescents.
- Shin Hye Kim, Byung Chul Ahn, Hyojee Joung, Mi Jung Park
- Endocrinol Metab. 2012;27(3):208-216. Published online September 19, 2012
- DOI: https://doi.org/10.3803/EnM.2012.27.3.208
- 3,766 View
- 67 Download
- 14 Crossref
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Abstract
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- BACKGROUND
The aim of this study is to investigate the distribution of plasma cholesterol and triglyceride levels as well as the prevalence of dyslipidemia among Korean adolescents. METHODS: We analyzed data for 3,045 adolescents aged 10-18 years (1,622 boys and 1,423 girls) who participated in the Korea National Health and Nutrition Examination Surveys from 2007 to 2010. RESULTS: The mean values of total cholesterol, triglycerides, low-density lipoprotein cholesterol (LDL-C), and high-density lipoprotein cholesterol (HDL-C) were 159, 89, 89, and 52 mg/dL, respectively. Plasma cholesterol levels were significantly higher in girls than those in boys (162.1 mg/dL vs. 155.6 mg/dL, P < 0.0001). The 90th percentile values of total cholesterol, triglycerides, and LDL-C were 192, 149, 117 mg/dL for boys, and 195, 147, 119 mg/dL for girls. The 10th percentile value of HDL-C was 38 mg/dL for boys and 40 mg/dL for girls. Triglyceride, LDL-C cholesterol levels increased, whereas plasma HDL-C levels decreased with increasing the body mass index (P < 0.0001) in both genders. Total cholesterol levels significantly increased with increasing the body mass index, especially in boys (P < 0.0001). The prevalence of dyslipidemia was 25.2% for boys and 21.7% for girls; this value significantly increased with overweight (37-40%) and obesity (53-56%). Independent predictors (odds ratio) of dyslipidemia were age (1.49), overweight (2.06), and obesity (5.11) for boys; overweight (1.95) and obesity (3.22) for girls. CONCLUSION: Adolescent dyslipidemia is strongly associated with obesity. Lipid screening for overweight or obese youths should be emphasized. Further, longitudinal studies examining the impact of childhood obesity and dyslipidemia on subsequent cardiovascular diseases are needed. -
Citations
Citations to this article as recorded by- Lipid Profile and the Frequency of Dyslipidemia in Iranian Adolescents with Severe Obesity, Who Were Candidates for Bariatric Surgery
Fahimeh Soheilipour, Fatemeh Geram
Obesity Surgery.2024; 34(2): 618. CrossRef - Screening and Management for Dyslipidemia in Korean Children and Adolescents
Jong Seo Yoon, Il Tae Hwang
The Ewha Medical Journal.2022;[Epub] CrossRef - Impact of the COVID-19 Pandemic on Seasonal Variations in Childhood and Adolescent Growth: Experience of Pediatric Endocrine Clinics
Jin-Ah Han, Yae-Eun Chung, In-Hyuk Chung, Yong-Hee Hong, Sochung Chung
Children.2021; 8(5): 404. CrossRef - Prevalence and treatment of pediatric dyslipidemia
Kyungchul Song, Ho-Seong Kim, Hyun Wook Chae
Journal of the Korean Medical Association.2021; 64(6): 410. CrossRef - Trends in Serum Lipid Profiles Among Korean Adolescents, 2007–2018
Da-Young Jeong, Shin-Hye Kim, Moon Young Seo, Sinyoung Kang, Mi Jung Park
Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy.2021; Volume 14: 4189. CrossRef - Trends of physiological and lifestyle risk factors of cardiovascular disease in Korea adolescents: Using Korean National Health and Nutrition Examination Survey data (2007–2015)
Yeo Jin Lee, Seon Young Hwang
Korean Journal of Health Education and Promotion.2020; 37(3): 85. CrossRef - 2017 Clinical practice guidelines for dyslipidemia of Korean children and adolescents
Jung Sub Lim, Eun Young Kim, Jae Hyun Kim, Jae-Ho Yoo, Kyung Hee Yi, Hyun Wook Chae, Jin-Ho Choi, Ji Young Kim, Il Tae Hwang
Annals of Pediatric Endocrinology & Metabolism.2020; 25(4): 199. CrossRef - 2017 Clinical practice guidelines for dyslipidemia of Korean children and adolescents
Jung Sub Lim, Eun Young Kim, Jae Hyun Kim, Jae-Ho Yoo, Kyung Hee Yi, Hyun Wook Chae, Jin-Ho Choi, Ji Young Kim, Il Tae Hwang
Clinical and Experimental Pediatrics.2020; 63(12): 454. CrossRef - Short Stature is Associated with Increased Risk of Dyslipidemia in Korean Adolescents and Adults
Na-Kyung Oh, Yun-Mi Song, Shin-Hye Kim, Mi Jung Park
Scientific Reports.2019;[Epub] CrossRef - Distribution of the Fasting Lipid Levels and Validation of the Reference Interval in Korean Adolescents
Seyoung Kwon, Youngak Na
The Korean Journal of Clinical Laboratory Science.2018; 50(3): 253. CrossRef - Impact of lifestyle factors on trends in lipid profiles among Korean adolescents: the Korea National Health and Nutrition Examination Surveys study, 1998 and 2010
Shin-Hye Kim, Young-Hwan Song, Sangshin Park, Mi-Jung Park
Korean Journal of Pediatrics.2016; 59(2): 65. CrossRef - Consumption of Added Sugars and Lipid Profiles in Korean Population from a Cohort Study
Sang Yeun Kim, Sun Ha Jee
Journal of Lipid and Atherosclerosis.2015; 4(1): 17. CrossRef - Dyslipidemia in Children and Adolescents: When and How to Diagnose and Treat?
Jung Min Yoon
Pediatric Gastroenterology, Hepatology & Nutrition.2014; 17(2): 85. CrossRef - The current state of dyslipidemia in Korean children and adolescents and its management in clinical practice
Jung Sub Lim
Annals of Pediatric Endocrinology & Metabolism.2013; 18(1): 1. CrossRef
- Lipid Profile and the Frequency of Dyslipidemia in Iranian Adolescents with Severe Obesity, Who Were Candidates for Bariatric Surgery
Review Article
- Endocrine Disrupting Chemicals and Pubertal Development.
- Shin Hye Kim, Mi Jung Park
- Endocrinol Metab. 2012;27(1):20-27. Published online March 1, 2012
- DOI: https://doi.org/10.3803/EnM.2012.27.1.20
- 2,122 View
- 34 Download
- 3 Crossref
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Abstract
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- During the past decades, advancement in pubertal onset especially in girls has been noticed worldwide. Genetic factors and increasing prevalence of adiposity may contribute, however ubiquitous presence of endocrine disrupting chemicals (EDCs) is suspected to be involved in the trend of earlier pubertal onset. Most of known EDCs have estrogenic and/or anti-androgenic actions and few have androgenic or anti-estrogenic effects. Some studies reported earlier age at menarche after exposure to polycholorinated biphenyls (PCBs), polybrominated biphenyls, dicholordiphenyltrichloroethane, phthalate esters, while several other studies found no effect of these compounds on Tanner stages or age at menarche in girls. Limited studies reported an association of delayed puberty in boys and exposure to PCBs or the pesticide endosulfan. However, epidemiological research on the effects of EDCs on sexual maturation is hampered by many pitfalls, such as the mixture of many chemicals with different effects in environment, unidentified critical window of exposure, and limited knowledge about the time lag between exposure and effect. In this paper, we reviewed possible mode of actions of different chemical compounds, and summarized animal/human studies shown the effects of EDCs on the pubertal development.
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Citations
Citations to this article as recorded by- Effects of Sleep Pattern, Stress, Menstrual Attitude, and Behavior That Reduces Exposure to Endocrine Disrupting Chemicals on Premenstrual Syndrome in Adolescents
Hye Jin Kim, So Young Choi, Haeyoung Min
Korean Journal of Women Health Nursing.2019; 25(4): 423. CrossRef - Relationship among Pro-environmental Attitude, Behavior to Decrease Exposure, Knowledge of Endocrine Disruptors, and Obesity-related Profiles in Nursing Students
Min A Kim
Journal of Korean Biological Nursing Science.2016; 18(3): 160. CrossRef - Comparison of growth and pubertal progression in wild type female rats with different bedding types
Byung Ho Kang, Shin-Hee Kim, Kyung A Jung, So Youn Kim, Sung-Hoon Chung, Young Shil Park, Kyung Lim Yoon, Kye Shik Shim
Annals of Pediatric Endocrinology & Metabolism.2015; 20(1): 53. CrossRef
- Effects of Sleep Pattern, Stress, Menstrual Attitude, and Behavior That Reduces Exposure to Endocrine Disrupting Chemicals on Premenstrual Syndrome in Adolescents
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